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Another limitation ofIHC is that it relies on a small number of pre-dened protein markers per tissue sec -tion to discover the presence or absence of the mutated protein. Other cells in the gland are enteroendocrine cells,not easily identified in routine H&E-stained paraffin sections, and, inthe deep part of the gland, undifferentiated cells of the replicative zone,derived from the stem cells in the base ofthe crypt. Despite these observations, combining ARBswith ACEIs has also been associated with more adverse effectsin some studies, including hypotension, renal insuficiency, andhyperkalemia

Despite these observations, combining ARBswith ACEIs has also been associated with more adverse effectsin some studies, including hypotension, renal insuficiency, andhyperkalemia.

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